Circulating Tumor Cells as Biomarkers in Clinical Development
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Free Trial CoursesOutline:Circulating Tumor Cells (CTCs) as biomarkers in clinical development. Non-hematopoietic malignancies are mostly characterized by invasion into other organs. Dissemination of cancer to other organs causing their destruction. Incidence of Bone Metastases in Cancers. Tumor Biology - CTCs and Metastasis. CTCs penetrate into the blood system. Metastasis Formation is Highly Inefficient. Capturing CTCs. Blood collection and centrifugation. Germ layers and their relevance to detection of CTCs. Capture of CTCs. Magnetic capture of CTCs. Analysis of Tumor Cells. CTC Expression by Cancer Type: Survey Study. Key Properties of Cancer Biomarkers. Specific to cancer. Assay is standardized, quantitative, and validated. Measurement can be obtained by non-invasive techniques. Biomarker stability can be maintained during shipping/storage/assay. Intra- and inter-observer variability should be minimal. Modulation of the biomarker correlates with clinical benefit. Serial monitoring is possible. Landmark Article, 'Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer' Cristofanilli, et al. A prospective, multicenter study. WHO Bidimensional CT Imaging. Partial Response (PR). Progressive Disease (PD). Stable Disease (S). Introduction to Kaplan-Meier. Non-parametric estimate of the survival function. Commonly used to describe survivorship of study populations. Commonly used to compare two study populations. Intuitive graphical presentation. CTCs as Prognostic Biomarkers. Prognostic biomarkers - definition. Prognostic biomarkers forecast the likely course of disease irrespective of treatment. CTCs as Predictive Biomarkers. Predictive biomarkers - definition. Predictive biomarkers forecast the likely response to treatment. Clinical Utility of CTCs in monitoring metastatic colorectal cancer (mCRC). Progression-free survival (PFS). Overall survival (OS). Current multicenter studies. CellTracks? Biomarker Reagents for CTC Characterization. Temporal profiles: patients with largest number of detectable CTCs at baseline. Circulating Tumor Cells - FISH Analysis. Final Remarks. | Objectives:Learn about metastasis and how CTCs disseminate. Learn how CTCs are captured and analyzed and used for their predictive and prognostic characteristics. Discuss several seminal scientific reports and implementation of CTCs in biomarker studies related to oncology drug development. | |
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