Combinatorial Chemistry

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Program/Course ID: COMCH Enrollment Period: 12 months. Average Learning Time: ~. Additional Resources: Supplemental materials & activities. Credit Hours: 3 credits. Method of Training: Online, asynchronous, self-paced eLearning. Accessibility: 24/7 access to all program materials. Demonstration: Four (4) free trial courses are available. Group/Employee Training: Click here to request a quote or invoice. Final Assessment: Multiple choice; unlimited attempts. Certificate: Encrypted PDF with QR validation code.

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Saturday, May 16, 2026 UPDATE:
This program is currently unavailable for enrollment.
It may have been updated or discontinued.
Check for newer version in our catalog.

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Outline: INTRODUCTION 1. Course Information 2. Interface Tour 3. Course Overview COMBICHEM OVERVIEW 2. Objectives 3. Medicinal Chemistry 4. Combinatorial Chemistry 5. High-Throughput Screening 6. HTS Assays 7. uHTS Requirements 8. Progress Check DIVERSITY ANALYSIS 9. Objectives 10. Selection and Diversity 11. Peptide Libraries 12. DNA Shuffling 13. Strategic Options 14. Molecular Diversity 15. Synthesis Strategies 16. Phage Display 17. Progress Check LIBRARY DESIGN 18. Objectives 19. Drug Pharmacophores 20. Library Design 21. Lead Optimization 22. Applications 23. Progress Check		Objectives: Define the two technologies that now allow the creation of large combinatorial libraries of compounds List the three functions that combinatorial chemistry brings to synthetic medicinal chemistry Describe the difference between the three different types of assays with which combinatorial libraries are usually tested Specify two of the features of an assay that allow it to be amenable to high-throughput screening Explain the advantages of HTRF-based assays Describe the three principal requirements needed to scale an assay to the level of uHTS Define the difference between a diverse library and a focused or biased library Calculate the number of combinations of molecules capable of being created from an n-mer peptide library List three classes of proteins that have been 'improved' using DNA shuffling Specify the strategic options available in the creation of a combinatorial library Describe how molecular diversity can be obtained in protein, peptide, nucleic-acid or small-molecule libraries Define and explain the two major strategies for synthesizing small-molecule libraries List the nine steps involved in creating antibodies via phage display Understand the key features of a drug pharmacophore List some of the parameters involved in designing combinatorial drug libraries Define the two major parameters in drug optimization that can benefit from drug design Give two examples of drugs that can now be synthesized by solid-phase combinatorial synthesis

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Comments: For quotes or invoices please provide the titles of the course(s) and number of students.	Combinatorial Chemistry